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Pauline presented a talk at EANM 2023

September 11, 2023

On Sept. 11, 2023, Pauline presented her reserach on Radioligand Therapy in GBM: Fibroblast Activation Protein (FAP) Promises at the 36th Annual Meeting of the European Association of Nuclear Medicine in Vienna (Autria).

Pauline and Fadi presented their research at SfN 2022

November 14, 2022

Pauline presented her poster “FAP Theranostics: Opportunities and Challenges in GBM” and Fadi presented his poster “Developing Peptide-Based Theranostic Probes Targeting the Apelin Receptor in Glioblastoma” at the Annual Conference of the Society for Neuroscience 2022 in San Diego on November 14, 2022.

Fadi presented at the 2022 UCLA Biomedical Research Minor Poster Symposium

August 18, 2022

Fadi presented his poster “Developing Peptide-Based Theranostic Probes Targeting the Apelin Receptor in Glioblastoma” at the 2022 UCLA Biomedical Research Minor Poster Symposium on August 18, 2022.

Pauline presented her latest results on FAP theranostics in GBM at SNMMI 2022

June 14, 2022

Pauline presented her poster “Fibroblast Activation Protein (FAP) as a Target for Radioligand Therapy in Glioblastoma” at the annual meeting of the Society of Nuclear Medicine and Molecular Imaging held in Vancouver, Canada on June 10-15, 2022. She also got rewarded with a Poster Prize (3rd Place) in Basic and Translational Oncology!

Neurotheranostics Program: Funding from UCLA School of Medicine and Jonsson Comprehensive Cancer Center

March 31, 2022

We received funding from the UCLA School of Medicine and the Jonsson Comprehensive Cancer Center for Tackling Glioblastoma Using Radioligand Therapy: The UCLA Neurotheranostics Program.

The Neurotheranostics program that will bring together the knowledge of GBM biology, radioligand therapy (RLT), and design of brain-penetrant ligands and pharmacology to effectively design targeted-RLT probes for the specific treatment of GBM. The program is focused on the identification of druggable targets at the surface of GBM tumors and the development of brain-penetrant molecules for PET imaging and RLT. 

Principal Investigators: Drs. Christine E. Mona, David A. Nathanson, and Elie Besserer-Offroy.
Co-Investigators: Drs. Guiseppe Carlucci, Timothy F. Cloughesy, and Johannes Czernin.

New publication in IJMS – Novel TRPC7 BRET-Based Biosensor

February 24, 2022

Pétigny C, Dumont AA, Giguère H, Collette A, Holleran BJ, Iftinca M, Altier C, Besserer-Offroy É, Auger-Messier M, Leduc R.
Monitoring TRPC7 Conformational Changes by BRET Following GPCR Activation.
Int J Mol Sci. 2022 Feb 24;23(5):2502.

PMID: 35269644     PMCID: PMC8910688

New publication in J. Med. Chem. – Biased Macrocyclic Analogs of Apelin

January 4, 2022

Tran K, Sainsily X, Côté J, Coquerel D, Couvineau P, Saibi S, Haroune L, Besserer-Offroy É, Flynn-Robitaille J, Resua Rojas M, Murza A, Longpré JM, Auger-Messier M, Lesur O, Bouvier M, Marsault É, Boudreault PL, Sarret P.
Size-Reduced Macrocyclic Analogues of [Pyr1]-apelin-13 Showing Negative Gα12 Bias Still Produce Prolonged Cardiac Effects.

J Med Chem. 2022 Jan 13;65(1):531-551
PMID: 34982553

Human BLT1 crystal is out in Nature Communications

May 20, 2021

Nice collaboration with Vadim Cherezov and Seva Katrich at USC Bridge Institute, and Merck for this new lipid GPCR crystal. Very proud to be part of this incredible project!

Michaelian N, Sadybekov A, Besserer-Offroy É, Han GW, Krishnamurthy H, Zamlynny B, Fradera X, Siliphaivanh P, Prestland J, Spencer K, Soisson S, Popov P, Sarret P, Katritch V, Cherezov V.
Structural Insights on Ligand Recognition at the Human Leukotriene B4 Receptor 1.
Nature Communications. 2021; (12):2971
PMID: 34016973

Join the Team !

January 30, 2021

We are looking for a talented and motivated Post-Doc Associate/Fellow to join the Besserer Lab!

1st Day !

January 19, 2021 / Leave a comment

Today is my first day as a Faculty, I still don’t believe it! It was a dream since I started grad school but now it’s a reality.