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New publication in IJMS – Novel TRPC7 BRET-Based Biosensor

February 24, 2022

Pétigny C, Dumont AA, Giguère H, Collette A, Holleran BJ, Iftinca M, Altier C, Besserer-Offroy É, Auger-Messier M, Leduc R.
Monitoring TRPC7 Conformational Changes by BRET Following GPCR Activation.
Int J Mol Sci. 2022 Feb 24;23(5):2502.

PMID: 35269644     PMCID: PMC8910688

New publication in J. Med. Chem. – Biased Macrocyclic Analogs of Apelin

January 4, 2022

Tran K, Sainsily X, Côté J, Coquerel D, Couvineau P, Saibi S, Haroune L, Besserer-Offroy É, Flynn-Robitaille J, Resua Rojas M, Murza A, Longpré JM, Auger-Messier M, Lesur O, Bouvier M, Marsault É, Boudreault PL, Sarret P.
Size-Reduced Macrocyclic Analogues of [Pyr1]-apelin-13 Showing Negative Gα12 Bias Still Produce Prolonged Cardiac Effects.

J Med Chem. 2022 Jan 13;65(1):531-551
PMID: 34982553

Human BLT1 crystal is out in Nature Communications

May 20, 2021

Nice collaboration with Vadim Cherezov and Seva Katrich at USC Bridge Institute, and Merck for this new lipid GPCR crystal. Very proud to be part of this incredible project!

Michaelian N, Sadybekov A, Besserer-Offroy É, Han GW, Krishnamurthy H, Zamlynny B, Fradera X, Siliphaivanh P, Prestland J, Spencer K, Soisson S, Popov P, Sarret P, Katritch V, Cherezov V.
Structural Insights on Ligand Recognition at the Human Leukotriene B4 Receptor 1.
Nature Communications. 2021; (12):2971
PMID: 34016973