Fadi presented his poster “Developing Peptide-Based Theranostic Probes Targeting the Apelin Receptor in Glioblastoma” at the 2022 UCLA Biomedical Research Minor Poster Symposium on August 18, 2022.
Pauline presented her poster “Fibroblast Activation Protein (FAP) as a Target for Radioligand Therapy in Glioblastoma” at the annual meeting of the Society of Nuclear Medicine and Molecular Imaging held in Vancouver, Canada on June 10-15, 2022. She also got rewarded with a Poster Prize (3rd Place) in Basic and Translational Oncology!
Neurotheranostics Program: Funding from UCLA School of Medicine and Jonsson Comprehensive Cancer Center
We received funding from the UCLA School of Medicine and the Jonsson Comprehensive Cancer Center for Tackling Glioblastoma Using Radioligand Therapy: The UCLA Neurotheranostics Program.
The Neurotheranostics program that will bring together the knowledge of GBM biology, radioligand therapy (RLT), and design of brain-penetrant ligands and pharmacology to effectively design targeted-RLT probes for the specific treatment of GBM. The program is focused on the identification of druggable targets at the surface of GBM tumors and the development of brain-penetrant molecules for PET imaging and RLT.
Monitoring TRPC7 Conformational Changes by BRET Following GPCR Activation.
Int J Mol Sci. 2022 Feb 24;23(5):2502.
PMID: 35269644 PMCID: PMC8910688
Nice collaboration with Vadim Cherezov and Seva Katrich at USC Bridge Institute, and Merck for this new lipid GPCR crystal. Very proud to be part of this incredible project!
Michaelian N, Sadybekov A, Besserer-Offroy É, Han GW, Krishnamurthy H, Zamlynny B, Fradera X, Siliphaivanh P, Prestland J, Spencer K, Soisson S, Popov P, Sarret P, Katritch V, Cherezov V.
Structural Insights on Ligand Recognition at the Human Leukotriene B4 Receptor 1.
Nature Communications. 2021; (12):2971
We are looking for a talented and motivated Post-Doc Associate/Fellow to join the Besserer Lab!
Today is my first day as a Faculty, I still don’t believe it! It was a dream since I started grad school but now it’s a reality.