Pauline presented her latest results on FAP theranostics in GBM at SNMMI 2022

Pauline presented her poster “Fibroblast Activation Protein (FAP) as a Target for Radioligand Therapy in Glioblastoma” at the annual meeting of the Society of Nuclear Medicine and Molecular Imaging held in Vancouver, Canada on June 10-15, 2022. She also got rewarded with a Poster Prize (3rd Place) in Basic and Translational Oncology!

Neurotheranostics Program: Funding from UCLA School of Medicine and Jonsson Comprehensive Cancer Center

We received funding from the UCLA School of Medicine and the Jonsson Comprehensive Cancer Center for Tackling Glioblastoma Using Radioligand Therapy: The UCLA Neurotheranostics Program.

The Neurotheranostics program that will bring together the knowledge of GBM biology, radioligand therapy (RLT), and design of brain-penetrant ligands and pharmacology to effectively design targeted-RLT probes for the specific treatment of GBM. The program is focused on the identification of druggable targets at the surface of GBM tumors and the development of brain-penetrant molecules for PET imaging and RLT. 

Principal Investigators: Drs. Christine E. Mona, David A. Nathanson, and Elie Besserer-Offroy.
Co-Investigators: Drs. Guiseppe Carlucci, Timothy F. Cloughesy, and Johannes Czernin.

New publication in IJMS – Novel TRPC7 BRET-Based Biosensor

Pétigny C, Dumont AA, Giguère H, Collette A, Holleran BJ, Iftinca M, Altier C, Besserer-Offroy É, Auger-Messier M, Leduc R.
Monitoring TRPC7 Conformational Changes by BRET Following GPCR Activation.
Int J Mol Sci. 2022 Feb 24;23(5):2502.

PMID: 35269644     PMCID: PMC8910688

New publication in J. Med. Chem. – Biased Macrocyclic Analogs of Apelin

Tran K, Sainsily X, Côté J, Coquerel D, Couvineau P, Saibi S, Haroune L, Besserer-Offroy É, Flynn-Robitaille J, Resua Rojas M, Murza A, Longpré JM, Auger-Messier M, Lesur O, Bouvier M, Marsault É, Boudreault PL, Sarret P.

Human BLT1 crystal is out in Nature Communications

Nice collaboration with Vadim Cherezov and Seva Katrich at USC Bridge Institute, and Merck for this new lipid GPCR crystal. Very proud to be part of this incredible project!

Michaelian N, Sadybekov A, Besserer-Offroy É, Han GW, Krishnamurthy H, Zamlynny B, Fradera X, Siliphaivanh P, Prestland J, Spencer K, Soisson S, Popov P, Sarret P, Katritch V, Cherezov V.
Structural Insights on Ligand Recognition at the Human Leukotriene B4 Receptor 1.
Nature Communications. 2021; (12):2971
PMID: 34016973

Join the Team !

We are looking for a talented and motivated Post-Doc Associate/Fellow to join the Besserer Lab!

1st Day !

Today is my first day as a Faculty, I still don’t believe it! It was a dream since I started grad school but now it’s a reality.

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Congratulations 🥳 to Pauline JEANJEAN, Post Doc in the @UCLA Ahmanson Translational Theranostics Division, for her poster prize🥉at the #SNMMI22 in Vancouver!

#nuclearmedicine #theranostics #cancerresearch #glioblastoma #braincancer #precisionmedicine #myUCLATeam #UCLA

Very sad news ... Marc has done so much for the field, I remember him as a simple, generous, and very talented scientist. Condolences to his family, friends and colleagues.

BryanRoth @zenbrainest

I am sad to report that a friend, colleague and giant in the field Marc Caron died last night. May he rest in peace.

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