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Peer-reviewed publications

Pétigny C, Dumont A-A, Giguère H, Collette A, Holleran BJ, Iftinca M, Altier C, Besserer-Offroy É, Auger-Messier M, Leduc R.
Monitoring TRPC7 Conformational Changes by BRET Following GPCR Activation.
International Journal of Molecular Sciences. 2022; 23(5):2502
PMID: TBD

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Tran K, Sainsily X, Côté J, Coquerel D, Couvineau P, Saibi S, Haroune L, Besserer-Offroy É, Flynn-Robitaille J, Resua Rojas M, Murza A, Longpré JM, Auger-Messier M, Lesur O, Bouvier M, Marsault É, Boudreault PL, Sarret P.
Size-Reduced Macrocyclic Analogues of [Pyr1]-apelin-13 Showing Negative Gα12 Bias Still Produce Prolonged Cardiac Effects.
Journal of medicinal chemistry. 2022; 65(1):531-551.
PMID: 34982553

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Michaelian N, Sadybekov A, Besserer-Offroy É, Han GW, Krishnamurthy H, Zamlynny B, Fradera X, Siliphaivanh P, Prestland J, Spencer K, Soisson S, Popov P, Sarret P, Katritch V, Cherezov V.
Structural Insights on Ligand Recognition at the Human Leukotriene B4 Receptor 1.
Nature Communications. 2021; (12):2971
PMID: 34016973

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Vivancos M, Fanelli R, Besserer-Offroy É, Beaulieu S, Chartier M, Resua-Rojas M, Mona CE, Previti S, Rémond E, Longpré JM, Cavelier F, Sarret P.
Metabolically stable neurotensin analogs exert potent and long-acting analgesia without hypothermia.
Behavioural Brain Research. 2021; 405:113189
PMID: 33607165

PubMed      Journal      Free Full-text article (arXiv.org)


Sadybekov AA, Brouillette RL, Marin E, Sadybekov AV, Luginina A, Gusach A, Mishin A, Besserer-Offroy É, Longpré JM, Borshchevskiy V, Cherezov V, Sarret P, Katritch V.
Structure-based virtual screening of ultra-large library yields potent antagonists for a lipid GPCR.
Biomolecules. 2020; 10(12):1634
PMID: 33287369

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Besserer-Offroy É*, Brouillette RL, Longpré JM, Sarret P.
Assessing Gαq/15-signaling with IP-One: Single plate transfection and assay protocol for cell-based high-throughput assay.
Bio-Protocol. 2020; 10(16):e3715
PMID: 33659379

*Corresponding Author

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Besserer-Offroy É*, Tétreault P*, Brouillette RL, René A, Murza A, Fanelli R, Kirby K, Parent AJ, Dubuc I, Beaudet N, Côté J, Longpré JM, Martinez J, Cavelier F, Sarret P.
Data set describing the in vitro biological activity of JMV2009, a novel silylated neurotensin(8-13) analog.
Data in Brief. 2020; 31C:105884
PMID: 32637491

*Co-First Authors

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Besserer-Offroy É*, Tétreault P*, Brouillette RL, René A, Murza A, Fanelli R, Kirby K, Parent AJ, Dubuc I, Beaudet N, Côté J, Longpré JM, Martinez J, Cavelier F, Sarret P.
Pain relief devoid of opioid side effects following central action of a silylated neurotensin analog.
European Journal of Pharmacology. 2020; 882C:173174
PMID: 32534076

*Co-First Authors

PubMed      Journal      Free Full-text article (arXiv.org)


Besserer-Offroy É*°, Brouillette RL*, Mona CE, Chartier M, Lavenus S, Sousbie M, Belleville K, Longpré JM, Marsault É, Grandbois M, Sarret P°.
Cell-penetrating pepducins targeting the neurotensin receptor type 1 relieve pain.
Pharmacological research. 2020; 155C:104750
PMID: 32151680

*Co-First Authors
°Co-Corresponding Authors

PubMed      Journal      Free Full-text article (arXiv.org)


Gusach A, Luginina A, Marin E, Brouillette RL, Besserer-Offroy É, Longpré JM, Ishchenko A, Popov P, Patel N, Fujimoto T, Maruyama T, B Stauch, Ergasheva M, Romanovskaia D, Stepko A, Kovalev K, Shevtsov M, Gordeliy V, Han GW, Katritch V, Borshchevskiy V, Sarret P, Mishin A, Cherezov V.
Structural basis of ligand selectivity and disease mutations in cysteinyl leukotriene receptors.
Nature Communications. 2019; (10):5573
PMID: 31811124

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Luginina A, Gusach A, Marin E, Mishin A, Brouillette RL, Popov P, Shiriaeva A, Besserer-Offroy É, Longpré JM, Lyapina E, Ishchenko A, Patel N, Polovinkin V, Safronova N, Bogorodskiy A, Edelweiss E, Hu H, Weierstall U, Liu W, Batyuk A, Gordeliy V, Han GW, Sarret P, Katritch V, Borshchevskiy V, Cherezov V.
Structure-Based Mechanism of Cysteinyl Leukotriene Receptor Inhibition by Antiasthmatic Drugs.
Science advances. 2019; 5(10):eaax2518
PMID: 31633023

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Boulkeroua C, Ayari H, Khalfaoui T, Lafrance M, Besserer-Offroy É, Ekindi N, Sabbagh R, Dumaine R, Lesur O, Sarret P, Chraibi A.
Apelin-13 Regulates Vasopressin-Induced Aquaporin-2 Expression and Trafficking in Kidney Collecting Duct Cells.
Cellular physiology and biochemistry. 2019; 53(4):687-700
PMID: 31577078

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*Besserer-Offroy É, Sarret P.
Sending out Biased Signals: An Appropriate Proposition for Pain?
Douleur et analgésie. 2019; 32(2):108-110.

*Corresponding Author

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Lavenus S, Simard É, Besserer-Offroy É, Froehlich U, Leduc R, Grandbois M.
Label-free cell signaling pathway deconvolution of angiotensin type 1 receptor reveals time-resolved G-protein activity and distinct AngII and AngIII/IV responses.
Pharmacological research. 2018; 136:108-120.
PMID: 29959993

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Sousbie M, Vivancos M, Brouillette RL, Besserer-Offroy É, Longpré JM, Leduc R, Sarret P, Marsault É.
Structural Optimization and Characterization of Potent Analgesic Macrocyclic Analogues of Neurotensin (8-13).
Journal of medicinal chemistry. 2018; 61(16):7103-7115.
PMID: 30035538

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St-Pierre D, Cabana J, Holleran BJ, Besserer-Offroy É, Escher E, Guillemette G, Lavigne P, Leduc R.
Angiotensin II cyclic analogs as tools to investigate AT<sub>1</sub>R biased signaling mechanisms.
Biochemical pharmacology. 2018; 154:104-117.
PMID: 29684376

PubMed      Journal      Free Full-text article (arXiv.org)      Supporting Information


Besserer-Offroy É, Bérubé P, Côté J, Murza A, Longpré JM, Dumaine R, Lesur O, Auger-Messier M, Leduc R, Marsault É, Sarret P.
The hypotensive effect of activated apelin receptor is correlated with β-arrestin recruitment.
Pharmacological research. 2018; 131:7-16.
PMID: 29530600

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Sousbie M, Besserer-Offroy É, Brouillette RL, Longpré JM, Leduc R, Sarret P, Marsault É.
In Search of the Optimal Macrocyclization Site for Neurotensin.
ACS medicinal chemistry letters. 2018; 9(3):227-232.
PMID: 29541365, PMCID: PMC5846049

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Besserer-Offroy É, Brouillette RL, Lavenus S, Froehlich U, Brumwell A, Murza A, Longpré JM, Marsault É, Grandbois M, Sarret P, Leduc R.
The signaling signature of the neurotensin type 1 receptor with endogenous ligands.
European journal of pharmacology. 2017; 805:1-13.
PMID: 28341345

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Fanelli R, Floquet N, Besserer-Offroy É, Delort B, Vivancos M, Longpré JM, Renault P, Martinez J, Sarret P, Cavelier F.
Use of Molecular Modeling to Design Selective NTS2 Neurotensin Analogues.
Journal of medicinal chemistry. 2017; 60(8):3303-3313.
PMID: 28368584

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Murza A, Sainsily X, Côté J, Bruneau-Cossette L, Besserer-Offroy É, Longpré JM, Leduc R, Dumaine R, Lesur O, Auger-Messier M, Sarret P, Marsault É.
Structure-activity relationship of novel macrocyclic biased apelin receptor agonists.
Organic & biomolecular chemistry. 2017; 15(2):449-458.
PMID: 27924341

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Mona CE, Besserer-Offroy É, Cabana J, Leduc R, Lavigne P, Heveker N, Marsault É, Escher E.
Design, synthesis, and biological evaluation of CXCR4 ligands.
Organic & biomolecular chemistry. 2016; 14(43):10298-10311.
PMID: 27752700

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Thomas JB, Vivancos M, Giddings AM, Wiethe RW, Warner KR, Murza A, Besserer-Offroy É, Longpré JM, Runyon SP, Decker AM, Gilmour BP, Sarret P.
Identification of 2-({[1-(4-Fluorophenyl)-5-(2-methoxyphenyl)-1H-pyrazol-3-yl]carbonyl}amino)tricyclo[3.3.1.13,7]decane-2-carboxylic Acid (NTRC-844) as a Selective Antagonist for the Rat Neurotensin Receptor Type 2.
ACS chemical neuroscience. 2016; 7(9):1225-31.
PMID: 27359371

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Mona CE, Besserer-Offroy É, Cabana J, Lefrançois M, Boulais PE, Lefebvre MR, Leduc R, Lavigne P, Heveker N, Marsault É, Escher E.
Structure-Activity Relationship and Signaling of New Chimeric CXCR4 Agonists.
Journal of medicinal chemistry. 2016; 59(16):7512-24.
PMID: 27434274

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Murza A, Sainsily X, Coquerel D, Côté J, Marx P, Besserer-Offroy É, Longpré JM, Lainé J, Reversade B, Salvail D, Leduc R, Dumaine R, Lesur O, Auger-Messier M, Sarret P, Marsault É.
Discovery and Structure-Activity Relationship of a Bioactive Fragment of ELABELA that Modulates Vascular and Cardiac Functions.
Journal of medicinal chemistry. 2016; 59(7):2962-72.
PMID: 26986036

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Hapău D, Rémond E, Fanelli R, Vivancos M, René A, Côté J, Besserer-Offroy É, Longpré JM, Martinez J, Zaharia V, Sarret P, Cavelier F.
Stereoselective Synthesis of β-(5-Arylthiazolyl) α-Amino Acids and Use in Neurotensin Analogues.
European journal of organic chemistry. 2016; 2016(5):1017-1024.

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*Besserer-Offroy É, *Fanelli R, René A, Côté J, Tétreault P, Collerette-Tremblay J, Longpré JM, Leduc R, Martinez J, Sarret P, Cavelier F.
Synthesis and Characterization in Vitro and in Vivo of (l)-(Trimethylsilyl)alanine Containing Neurotensin Analogues.
Journal of medicinal chemistry. 2015; 58(19):7785-95.
PMID: 26348111

* Co-First Authors

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Murza A, Besserer-Offroy É, Côté J, Bérubé P, Longpré JM, Dumaine R, Lesur O, Auger-Messier M, Leduc R, Sarret P, Marsault É.
C-Terminal modifications of apelin-13 significantly change ligand binding, receptor signaling, and hypotensive action.
Journal of medicinal chemistry. 2015; 58(5):2431-40.
PMID: 25668242

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Demeule M, Beaudet N, Régina A, Besserer-Offroy É, Murza A, Tétreault P, Belleville K, Ché C, Larocque A, Thiot C, Béliveau R, Longpré JM, Marsault É, Leduc R, Lachowicz JE, Gonias SL, Castaigne JP, Sarret P.
Conjugation of a brain-penetrant peptide with neurotensin provides antinociceptive properties.
The Journal of clinical investigation. 2014; 124(3):1199-213.
PMID: 24531547, PMCID: PMC3934173

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Murza A, Parent A, Besserer-Offroy É, Tremblay H, Karadereye F, Beaudet N, Leduc R, Sarret P, Marsault É.
Elucidation of the structure-activity relationships of apelin: influence of unnatural amino acids on binding, signaling, and plasma stability.
ChemMedChem. 2012; 7(2):318-25.
PMID: 22170700

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Congratulations 🥳 to Pauline JEANJEAN, Post Doc in the @UCLA Ahmanson Translational Theranostics Division, for her poster prize🥉at the #SNMMI22 in Vancouver!

#nuclearmedicine #theranostics #cancerresearch #glioblastoma #braincancer #precisionmedicine #myUCLATeam #UCLA

Very sad news ... Marc has done so much for the field, I remember him as a simple, generous, and very talented scientist. Condolences to his family, friends and colleagues.

BryanRoth @zenbrainest

I am sad to report that a friend, colleague and giant in the field Marc Caron died last night. May he rest in peace.

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